This is the item build I use when I play as Lyra. She goes well with pretty much any team as long as your teammates take the healing and escape advantages she gives. The best team for this Lyra is with at least one other ranged attacker she can pair up with. I usually go in the lane with another hero, but I do not recommend this since the rest of the enemy team is likely to attack you and push the lane even harder than you were.
Lyra is vulnerable to whole enemy team attacks when she is on her own or with one other teammate since enemy heroes tend to try to surround her first. It makes a very difficult escape when she is slowed or stunned, so enemy heroes with those types of abilities are threatening because of her fragility and slow cool downs.
I apologize if I made any errors in this article.
This is my first guide.
Friendly, constructive criticism is welcomed.
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